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SOLOT-Eye

Development stage: Unknown
Lead developer: Stainwei
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Ophthalmic

Overview

SOLOT-Eye is a humanized anti-VEGF monoclonal antibody (hPV19) developed by Stainwei Biotechnology for the treatment of neovascular retinal diseases. It functions by binding to and neutralizing vascular endothelial growth factor (VEGF), which is a key driver of pathological angiogenesis and vascular permeability in conditions such as age-related macular degeneration (AMD) and diabetic macular edema (DME). Administered via ophthalmic injection, SOLOT-Eye is a specific formulation of the hPV19 antibody, which is also being evaluated in clinical trials for solid tumors under the name Affecizx. The drug works by neutralizing VEGF-driven ocular neovascularization to prevent vision loss in retinal disorders.

Brand names: AffecizxSuloxue
Other names: 苏洛晍眼用注射液hPV19 monoclonal antibody ophthalmic injectionhPV-19 monoclonal antibody ophthalmic injectionhPV 19 monoclonal antibody ophthalmic injectionSuloxue ophthalmic injection

Targets

VEGFA (Vascular endothelial growth factor A)

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