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soluble corn fiber
- Development stage
- Unknown
- Lead developer
- Phoenix Children's
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Soluble corn fiber is a prebiotic dietary fiber supplement being investigated by Phoenix Children's Hospital for the treatment of pediatric asthma. It functions via the gut-lung axis mechanism, where gut microbiota ferment the fiber into short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate. These metabolites act as immunomodulators that reduce Type-2 airway inflammation and improve asthma control. Clinical trials, including Phase 2 studies, have evaluated its efficacy in children aged 6-17, often using specific commercial formulations like PROMITOR (manufactured by Tate & Lyle) or NOVELOSE 3490 (a soluble tapioca starch from Ingredion used in more recent trials).
- Brand names
- PROMITORNOVELOSE 3490NOVELOSE3490NOVELOSE-3490
- Other names
- soluble corn fiberprebiotic dietary fiber
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