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soluble heparin-binding epidermal growth factor-like growth factor
- Development stage
- Phase 1
- Lead developer
- Pfizer
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intravesical
01
Overview
TTI-1612 is a recombinant, soluble form of heparin-binding epidermal growth factor-like growth factor (HB-EGF), developed by Trillium Therapeutics. It acts as an HBEGF modulator and is designed to correct dysfunction and restore the bladder epithelium to a normal, healthy state. The drug has been investigated primarily for urogenital diseases such as interstitial cystitis/bladder pain syndrome (IC/BPS) and has also received orphan drug designation in the US and Europe for the prevention of necrotizing enterocolitis (NEC). Its mechanism involves modulation of HBEGF activity, which plays a role in epithelial repair processes[1][2][3][4][8].
- Other names
- soluble HB-EGF like growth factorsoluble heparin-binding epidermal growth factor-like growth factor
02
Targets
HSPG (Basement membrane-specific heparan sulfate proteoglycan core protein (perlecan))EGFR T790M (Epidermal growth factor receptor T790M mutant)ERBB4 (Erb-b2 receptor tyrosine kinase 4)
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