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soluble Tie2 receptor
- Development stage
- Preclinical
- Lead developer
- Regeneron Pharmaceuticals
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Intramuscular, Intratumoral, Intravenous, Intravitreal
01
Overview
Soluble Tie2 receptor (often referred to as sTie2, sTie2-Fc, or ExTek) is a recombinant soluble decoy receptor consisting of the extracellular domain of the Tie2 (TEK) receptor tyrosine kinase, typically fused to an Fc domain or a histidine tag. It acts as a trap or decoy for the Tie2 ligands, Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2), thereby preventing them from binding to and activating endogenous cell-surface Tie2 receptors. Soluble Tie2 receptor is widely used as a research reagent and preclinical therapeutic candidate to study and inhibit pathological angiogenesis, tumor growth, metastasis, osteoclastogenesis, and inflammatory conditions such as arthritis.
- Other names
- ExTekExTek.6HissTie2sTie-2sTie 2sTie2-FcsTie-2-FcsTie 2-Fcsoluble TEKsoluble Tek receptorsoluble Tie2-Fc
02
Targets
ANGPT2 (Angiopoietin-2)ANGPT1 (Angiopoietin-1)
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