soluble toll-like receptor 2

Soluble toll-like receptor 2 (sTLR2) is a naturally occurring soluble form of the Toll-like receptor 2 (TLR2) protein that acts as an endogenous negative regulator of TLR-mediated inflammatory responses. Discovered and developed by researchers at Cardiff University, sTLR2 functions as a decoy receptor that binds to TLR2 ligands (such as pathogen-associated molecular patterns [PAMPs] and damage-associated molecular patterns [DAMPs]) and also physically associates with the TLR co-receptor CD14. By binding CD14, sTLR2 disrupts the interaction of TLR2 with CD14 and additionally inhibits other CD14-dependent receptors, notably TLR4. Preclinical studies have demonstrated its therapeutic potential in preventing peritoneal dialysis-associated fibrosis, reducing systemic inflammation, and ameliorating chronic kidney disease (CKD)-associated atherosclerotic disease without compromising bacterial clearance.

Other names

recombinant human soluble TLR2recombinant soluble TLR2soluble TLR2sTLR2sTLR-2sTLR 2