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SoluMatrix naproxen
- Development stage
- Unknown
- Lead developer
- Iroko Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**SoluMatrix naproxen** is a proprietary nanoparticle formulation of the nonsteroidal anti-inflammatory drug (NSAID) naproxen, designed to enhance solubility, absorption, and potentially reduce gastrointestinal side effects compared to standard naproxen. Naproxen inhibits cyclooxygenase (COX)-1 and COX-2 enzymes, reducing prostaglandin synthesis to provide analgesic, antipyretic, and anti-inflammatory effects. Developed using SoluMatrix technology by Durect Corporation, it targets pain, inflammation, and conditions like osteoarthritis, rheumatoid arthritis, and acute gout, with FDA approval for oral suspension in juvenile idiopathic arthritis and other indications.
- Brand names
- SoluMatrix naproxen
- Other names
- SoluMatrix naproxensubmicron naproxen
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)
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