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Drug intelligence / Profile preview
solvent-free itraconazole Complex IR
- Development stage
- Preclinical
- Lead developer
- Harvest Moon Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Solvent-free itraconazole Complex IR is a specialized oral immediate-release formulation of the triazole antifungal agent itraconazole, developed by Harvest Moon Pharmaceuticals. Itraconazole exerts its antifungal effect by inhibiting the fungal enzyme lanosterol 14-alpha-demethylase (CYP51), a cytochrome P450-dependent enzyme essential for converting lanosterol to ergosterol. The resulting depletion of ergosterol and accumulation of methylated sterol precursors disrupt fungal cell membrane integrity and function. This specific formulation utilizes a solvent-free complexation approach intended to enhance the bioavailability and solubility of itraconazole, which is traditionally poorly soluble, without the use of organic solvents. It is being developed as a complex generic or improved formulation for the treatment of various fungal infections.
- Other names
- itraconazole Complex IRsolvent-free itraconazole
02
Targets
CYP51A1 (Sterol 14α-demethylase)
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