Sominex Composto

Sominex Composto is a traditional herbal medicinal product developed and manufactured by EMS S/A in Brazil. It is a fixed-dose combination of three plant extracts: *Valeriana officinalis* (Valerian), *Crataegus oxyacantha* (Hawthorn), and *Passiflora incarnata* (Passionflower). The product is indicated as a mild sedative and for the treatment of sleep disturbances (insomnia) associated with anxiety. Its mechanism of action involves the synergistic modulation of the GABAergic system, primarily through interactions with Gamma-aminobutyric acid type A (GABA-A) and type B (GABA-B) receptors. Valerian and Passionflower are known to enhance GABAergic signaling, leading to reduced cerebral activity and sleep induction, while Hawthorn contributes relaxing properties that help alleviate anxiety symptoms. It is formulated as an oral small molecule product.

Brand names

Sominex CompostoSominex

Other names

Valeriana officinalis + Crataegus oxyacantha + Passiflora incarnata