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SON-DP
- Development stage
- Phase 1
- Lead developer
- Qurgen
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
SON-DP is a transcription factor (TF) protein drug with potential antineoplastic activity, currently in Phase I clinical trials for the treatment of advanced and metastatic solid tumors, including breast, ovarian, pancreatic, and colorectal cancers. Upon administration, SON-DP induces pluripotent reprogramming in cancer cells to generate transient induced pluripotent stem cells (tiPSCs), which then rapidly re-differentiate into normal tissue cells. This mechanism aims to convert malignant tumor cells back into non-cancerous tissue in situ. The drug is administered intravenously and is based on protein-induced in-situ cell reprogramming technology. Qurgen developed this agent as part of its pipeline of transcription factor drugs targeting various diseases[1][2][3][4][5][8].
- Other names
- transcription factor protein SON-DP
02
Targets
SON (Transcription factor SON)
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