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sonrotoclax

Development stage: Approved
Lead developer: BeOne Medicines
Modality: Small Molecules
Administration: Oral

Overview

Sonrotoclax is an investigational **oral small-molecule BH3 mimetic** and **next-generation BCL2 inhibitor** being developed by **BeOne Medicines** for B-cell malignancies. It is designed to bind selectively and potently to **B-cell lymphoma 2**, restoring apoptosis in malignant B cells; company and conference materials describe it as more selective and pharmacologically more potent than venetoclax, with a shorter half-life and no drug accumulation. Publicly described development includes monotherapy and combination studies in **mantle cell lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, Waldenström macroglobulinemia, marginal zone lymphoma, non-Hodgkin lymphoma subtypes, and t(11;14)-positive multiple myeloma**, with phase 3 programs underway in relapsed/refractory CLL/SLL and mantle cell lymphoma.

Brand names: Beqalzi
Other names: sonrotoclax

Targets

BCL-2 (BCL-2 family)

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