Drug intelligence / Profile preview

sontigidomide

Development stage: Preclinical
Modality: PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules

Overview

**Sontigidomide** is a small molecule antineoplastic agent in early development, characterized as a PROTAC degrader targeting GSPT1 and IKZF1/3. It demonstrates potent antiproliferative activity, inhibiting over 80% proliferation of MOLM-13 acute myeloid leukemia cells at 1 μM after 3 days, and shows efficacy against AML and solid tumor cells. Its structure features a racemic N-substituted glutarimide moiety akin to thalidomide derivatives, with proposed INN status by WHO, indicating preclinical to early clinical evaluation for oncology.

Targets

GSPT1 (G1 to S phase transition 1)IKZF3 (Zinc finger protein Aiolos)CRBN (Cereblon)IKZF1 (Ikaros family zinc finger protein 1)

Beyond the preview

Go deeper on sontigidomide.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on sontigidomide.

Explore the full profile