sophoraflavanone G

**Sophoraflavanone G** is a naturally occurring flavonoid compound isolated primarily from *Sophora flavescens* and other *Sophora* species. It is a plant-derived small molecule bearing antioxidant, anti-inflammatory, antitumor, and notable antimicrobial activities, especially against antibiotic-resistant bacteria. Mechanistically, sophoraflavanone G demonstrates anti-tumor activity via induction of apoptosis in cancer cells (e.g., triple-negative breast cancer and leukemia) mediated, at least in part, by suppression of MAPK-related pathways. In immune models, it attenuates airway hyper-responsiveness and inflammation likely by inhibiting Th2 cytokine secretion and reducing oxidative stress. Preclinical research also indicates synergism with several antibiotics, enhancing their effectivity against resistant bacterial strains. Although studied for diverse pharmacological activities, it is primarily used in research; there is no evidence of clinical approval as a pharmaceutical or dietary supplement[1][3][4][5][6][7].

Other names

kushenol Fnorkurarinonevexibinol(-)-vexibinolkushenin