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Sorbolene cream is a topical emollient and humectant formulation typically containing 10% glycerine along with paraffin and mineral oils. It is used to maintain skin hydration and barrier function. In clinical oncology, specifically within the Trans Tasman Radiation Oncology Group (TROG) 04.01 trial, it was utilized as the standard-of-care control for the prophylactic management of radiation dermatitis in breast cancer patients receiving post-mastectomy radiotherapy. The cream works by attracting moisture to the stratum corneum and providing an occlusive layer to prevent transepidermal water loss, thereby mitigating the severity of radiation-induced skin reactions.
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