Drug intelligence / Profile preview

sorbolene with vitamin E

Development stage
Unknown
Lead developer
Children's Hospital at Westmead
Modality
Small Molecules
Administration
Topical
01

Overview

Sorbolene with Vitamin E is a topical over-the-counter emollient and moisturizer widely used in Australia. It consists of a sorbolene (aqueous cream) base combined with Vitamin E (tocopherol), which acts as a lipid-soluble antioxidant to support skin barrier function and reduce oxidative stress in healing tissue. In clinical trials, such as the Paediatric Sternotomy Scar Management study conducted by The Children's Hospital at Westmead, it is utilized as a standard-of-care comparator to evaluate the efficacy of early silicone-based scar therapies (e.g., Stratamed and Strataderm) in preventing and treating abnormal sternotomy scarring in infants undergoing cardiac surgery.

Brand names
Redwin Sorbolene with Vitamin EKenkay Sorbolene with Vitamin E
Other names
sorbolene cream with vitamin Eaqueous cream with vitamin E
02

Targets

Stratum corneum lipid matrixStratum corneum waterPKC (Protein kinase C family)

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