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SOT114
- Development stage
- Preclinical
- Lead developer
- SOTIO Biotech AG
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
SOT114 is a preclinical-stage bispecific antibody-drug conjugate (ADC) being developed by SOTIO Biotech in collaboration with NBE-Therapeutics (a subsidiary of Boehringer Ingelheim) for the treatment of solid tumors. The therapeutic candidate is designed to simultaneously target two distinct tumor-associated antigens, leveraging bispecific binding to improve tumor selectivity, enhance internalization, and overcome tumor heterogeneity. SOT114 utilizes NBE-Therapeutics' proprietary site-specific SMAC-Technology™ (Sortase-Mediated Antibody Conjugation) to attach a potent anthracycline-based cytotoxic payload, aiming to deliver targeted cell-killing activity while minimizing off-target toxicity.
- Other names
- SOT 114SOT114SOT-114
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