sotalol

Sotalol is a beta-blocker with Class III antiarrhythmic properties that affects the heart and circulation within the atrium and ventricles. It works through two primary mechanisms: 1) As a non-selective beta-blocker, it prevents catecholamines from binding to β1 and β2 adrenergic receptors, which decreases heart rate and contractility. 2) As a Class III antiarrhythmic, it blocks potassium channels, prolonging repolarization and increasing the time before another electrical signal can be generated in ventricular myocytes. Sotalol is primarily used to treat life-threatening ventricular arrhythmias and to maintain normal sinus rhythm in patients with atrial fibrillation or flutter. It was first developed in 1960 and received FDA approval as an oral tablet on October 30, 1992.

Brand names

BetapaceBetapace AFSorineSotalol Hydrochloride AFSotylize

Other names

sotalol hydrochloride盐酸索他洛尔