sotetsuflavone

Sotetsuflavone is a naturally occurring biflavonoid compound isolated from plants such as Cycas revoluta and Taxus cuspidata. It exhibits notable anti-cancer properties in preclinical studies. Mechanistically, sotetsuflavone inhibits proliferation, migration, and invasion of non-small cell lung cancer (NSCLC) cells by inducing apoptosis (via upregulation of cytochrome C, cleaved-caspase 3/9 and Bax; downregulation of Bcl-2), causing G0/G1 cell cycle arrest (by reducing cyclin D1 and CDK4), and promoting autophagy through inhibition of the PI3K/Akt/mTOR signaling pathway. Additionally, it is a potent inhibitor of Dengue virus NS5 RNA-dependent RNA polymerase with an IC50 value around 0.16 μM[2][4][5]. Sotetsuflavone has not been approved for clinical use but shows promise as an anti-tumor agent in preclinical models.

Other names

8-[5-(5,7-dihydroxy-4-oxo-chromen-2-yl)-2-hydroxyphenyl]-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-chromen-4-one2608-21-1Sotetsuflavon