Southern Medical Univ. PDE4D compound 12C

Southern Medical Univ. PDE4D compound 12C: sourced facts only. name: "Among these compounds, 12C bearing a 2-(piperidin-1-yl)ethoxy group at the 6-position of indanone ring displayed satisfactory inhibitory activities and selectivity against AChE (IC50 = 0.28 μM) and PDE4D (IC50 = 1.88 μM)." [PMID:35689855]; target: "Among these compounds, 12C bearing a 2-(piperidin-1-yl)ethoxy group at the 6-position of indanone ring displayed satisfactory inhibitory activities and selectivity against AChE (IC50 = 0.28 μM) and PDE4D (IC50 = 1.88 μM)." [PMID:35689855]; developer: "Innovation Program of Drug Research on Neurological and Metabolic Diseases, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China." [PMID:35689855]; stage: "Moreover, 12C exhibited comparable AChE inhibitory activity with donepezil in the hippocampus of AD model mice." [PMID:35689855]