Drug intelligence / Profile preview

Southern Medical Univ. TREK1 compound 6u

Development stage
Unknown
Lead developer
Southern Medical University
01

Overview

Southern Medical Univ. TREK1 compound 6u: sourced facts only. name: "Our results manifested that compound 6u was a dual inhibitor of VRAC/TREK1 channels with IC50s of 7.11 ± 0.94 μM and 4.43 ± 0.90 μM, respectively." [PMID:35278418]; target: "Our results manifested that compound 6u was a dual inhibitor of VRAC/TREK1 channels with IC50s of 7.11 ± 0.94 μM and 4.43 ± 0.90 μM, respectively." [PMID:35278418]; developer: "School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, China." [PMID:35278418]; stage: "On top of that, our data demonstrated that 6u impaired interferon production in a concentration-dependently manner by dampening cGAS-cGAMP-STING pathway without any cytotoxicity when it comes to herpes simplex virus type 1 (HSV1) infection." [PMID:35278418]

02

Targets

KCNK2 (Potassium channel subfamily K member 2)

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