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SOXAP
- Development stage
- Preclinical
- Lead developer
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
SOXAP is a multi-drug chemotherapy regimen primarily investigated for the treatment of gastric cancer. This regimen combines four distinct agents: S-1, an oral fluoropyrimidine derivative; oxaliplatin, a platinum-based chemotherapy drug; apatinib, an anti-angiogenic tyrosine kinase inhibitor; and camrelizumab, an immune checkpoint inhibitor. The combination aims to provide a comprehensive therapeutic approach by targeting cancer cells through various mechanisms, including DNA damage, antimetabolite action, inhibition of tumor angiogenesis, and activation of the immune system against cancer cells.
02
Targets
DNAVEGFR2 (Vascular endothelial growth factor receptor 2)KIT (c-KIT proto-oncogene receptor tyrosine kinase)SRC (Proto-oncogene tyrosine-protein kinase Src)PDCD1 (Programmed cell death protein 1 receptor)
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