SP4160

SP4160 is a synthetic small molecule belonging to the class of leucine derivatives. It has been studied as a high-affinity ligand that binds to interleukin 2 (IL‑2), mimicking the binding site of the IL‑2 alpha receptor (IL‑2Rα). By targeting critical "hot spot" residues on IL‑2, it blocks the interaction between IL‑2 and its alpha receptor subunit. This mechanism suggests potential utility in modulating immune responses where IL‑2 signaling is involved. The compound was developed by Sunesis Pharmaceuticals primarily as a research tool for studying protein-protein interactions involving cytokines[9][1].

Other names

2-GUANIDINO-4-METHYL-PENTANOIC ACID [2-(4-{5-[4-(4-ACETYLAMINO-BENZYLOXY)-2,3-DICHLORO-PHENYL]-2-METHYL-2H-PYRAZOL-3-YL}-PIPERIDIN-1-YL)-2-OXO-ETHYL]-AMIDE(2R)-N-[2-[4-[5-[4-[(4-acetamidophenyl)methoxy]-2,3-dichlorophenyl]-2-methylpyrazol-3-yl]piperidin-1-yl]-2‑oxoethyl]-2-(diaminomethylideneamino)-4-methylpentanamide