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SPARC001

Development stage: Unknown
Lead developer: SPARC
Modality: Small Molecules
Administration: Oral

Overview

SPARC001 is an abuse-deterrent formulation of the combination analgesic hydrocodone bitartrate and acetaminophen, developed by Sun Pharma Advanced Research Company (SPARC). It is designed to provide effective pain management while reducing the potential for misuse and abuse, particularly through common tampering routes such as crushing for snorting or extraction for injection. The formulation aims to maintain the therapeutic efficacy and pharmacokinetic profile of standard immediate-release hydrocodone/acetaminophen combinations (such as Norco) while incorporating physical and chemical barriers to tampering. SPARC001 has been evaluated in clinical trials focusing on relative bioavailability and abuse potential in recreational opioid users.

Other names: hydrocodone bitartrate + acetaminophen abuse-deterrent formulation

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)MOR (Mu opioid receptor)

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