Drug intelligence / Profile preview

sparfloxacin

Development stage
Discontinued
Lead developer
Sanofi
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Sparfloxacin is a synthetic fluoroquinolone antibiotic used to treat bacterial respiratory infections such as bronchitis and pneumonia, as well as sinusitis. It acts by inhibiting bacterial DNA gyrase, an essential enzyme for DNA replication, repair, deactivation, and transcription in bacteria. This inhibition disrupts bacterial cell division and leads to cell death. Sparfloxacin exhibits broad-spectrum activity against both gram-positive and gram-negative organisms. It has been withdrawn from the U.S. market due to safety concerns but may still be available elsewhere[1][2][3][5][6].

Brand names
ZagamZagam Respipac
Other names
sparfloxacin
02

Targets

DNA gyraseTopo IV (Bacterial Topoisomerase IV)

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