sparteine

Sparteine is a plant-derived quinolizidine alkaloid found predominantly in Cytisus scoparius and Lupinus mutabilis. It acts as a class 1a antiarrhythmic agent by blocking sodium channels in cardiac tissue and has been used experimentally for its antiarrhythmic properties[2][3][4][5]. Sparteine also exhibits anticonvulsant effects in animal models and may decrease neuronal hyperexcitability through activation of M2 and M4 muscarinic acetylcholine receptors[6]. Although previously marketed under names such as Spal (Taiwan) and Sparteine (Brazil), it is not currently FDA-approved for human use due to safety concerns; its salts have been withdrawn or removed from several markets[1][5]. Additionally sparteine has applications as a chiral base in organic synthesis.

Brand names

SpalSparteine

Other names

(-)-sparteinelupinidineL-sparteine7,14-methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine dodecahydro-, (7S-(7alpha,7aalpha,14alpha,14abeta))(1S,2R,9S,10S)-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecane