Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
SPED
- Development stage
- Preclinical
- Administration
- Oral, Intravenous, Intranasal, Rectal, Intramuscular, Subcutaneous
01
Overview
SPED (rhamnan-type sulfated polysaccharide derivative) is a novel marine-derived candidate being developed as a hypoglycemic agent for type 2 diabetes. It is prepared from a sulfated polysaccharide (SPE) derived from *Enteromorpha prolifera* through specific enzymatic hydrolysis. SPED has demonstrated the ability to improve glucose metabolism and promote the PI3K/PKB/GSK-3β signaling pathway by regulating the mRNA expression of insulin receptors (IR), insulin receptor substrate 2 (IRS-2), phosphatidylinositol 3 kinase (PI3K), protein kinase B (PKB), and glycogen synthase kinase 3β (GSK-3β). Acute and sub-acute toxicity studies in mice showed no damaging effects, indicating a favorable safety profile.
02
Targets
GSK3 (Glycogen synthase kinase 3 beta)INSR (Insulin receptor)IRS2 (Insulin receptor substrate 2)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)AKT (RAC-alpha serine/threonine-protein kinase)
Beyond the preview
Go deeper on SPED.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on SPED.