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SPESN38
- Development stage
- Unknown
- Lead developer
- Sunstate Biosciences
- Modality
- Small Molecules, Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
SPESN38 is a novel formulation of SN38 (7-ethyl-10-hydroxycamptothecin), the active metabolite of irinotecan, developed using Sunstate Biosciences' proprietary single protein encapsulation (SPE) platform. This technology encapsulates the potent but poorly water-soluble antineoplastic agent SN38 within a single protein, specifically human serum albumin (HSA), without the use of artificial nanoparticles or chemical modifications. By improving solubility and delivery, SPESN38 aims to overcome the low enzymatic conversion rates associated with irinotecan and reduce systemic toxicity. Preclinical studies have demonstrated significant antitumor efficacy across various models, including Ewing sarcoma, rhabdomyosarcoma, soft tissue sarcoma, colorectal cancer, and non-small cell lung cancer. The FDA has cleared an Investigational New Drug (IND) application for SPESN38-8 for clinical development.
- Other names
- Single protein encapsulated SN38HSA-encapsulated SN38
02
Targets
TOP1 (DNA Topoisomerase I)
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