SPG-178

SPG-178 is a neutral, synthetic self-assembling peptide (SAP) hydrogel developed as a versatile scaffold for tissue engineering and regenerative medicine. It consists of short peptides that spontaneously form a stable, transparent nanofiber hydrogel in a neutral pH environment upon exposure to electrolytes. Unlike earlier SAP hydrogels such as RADA16, which are acidic, SPG-178 maintains a neutral pH, significantly reducing tissue irritation and inflammation. The material is non-biological, non-cytotoxic, and biocompatible, making it suitable for a wide range of clinical applications. It has been investigated as a topical hemostatic agent, a vitreous substitute in ophthalmic surgery, a scaffold for bone and periodontal regeneration, a neuroprotective agent in spinal cord injury, and a tool to prevent pancreatic fistulas after surgery. Its mechanical properties, including viscoelasticity, can be tuned by adjusting peptide and salt concentrations to suit specific biomedical needs.

Brand names

PanaceaGel

Other names

SPG-178-GelSPG178-GelSPG 178-Gelself-assembling peptide hydrogel SPG-178