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SPH-104

Development stage: Preclinical
Lead developer: Sapphire Therapeutics
Modality: Small Molecules
Administration: Oral

Overview

SPH-104 is an oral, discovery-stage drug candidate being developed by Sapphire Therapeutics for the treatment of microscopic colitis. The compound targets a novel, undisclosed receptor that modulates the NFkB and IL-22 signaling pathways. Unlike traditional immunosuppressive therapies for inflammatory bowel disease, SPH-104 utilizes a non-immunosuppressive approach intended to promote mucosal healing and restore intestinal barrier function. The drug is part of a pipeline of candidates derived from Sapphire's proprietary platform focusing on non-immunosuppressive pathways for gastrointestinal diseases.

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