Drug intelligence / Profile preview

SPH-105

Development stage: Preclinical
Lead developer: Sapphire Therapeutics
Administration: Rectal

Overview

SPH-105 is an investigational, discovery-stage therapeutic candidate being developed by Sapphire Therapeutics for the treatment of ulcerative proctitis. Designed for rectal administration, the drug utilizes a non-immunosuppressive approach by targeting a novel, undisclosed receptor that modulates the NFkB and IL-22 signaling pathways. This mechanism is intended to promote mucosal healing and resolve inflammation in the rectum without the systemic side effects typically associated with traditional immunosuppressive therapies for inflammatory bowel disease.

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