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SPH5008-A

Development stage: Unknown
Lead developer: Shanghai Pharmaceuticals
Modality: Small Molecules
Administration: Oral

Overview

SPH5008-A is a small molecule therapeutic candidate being developed by Shanghai Pharmaceuticals for the treatment of arthritis-related diseases. It is a sustained-release formulation of lornoxicam, a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class. Lornoxicam functions as a potent inhibitor of the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which are responsible for the production of prostaglandins that mediate pain and inflammation. By utilizing a sustained-release delivery system, SPH5008-A aims to maintain therapeutic plasma concentrations over a longer period, potentially reducing dosing frequency and improving patient compliance compared to immediate-release lornoxicam. The drug is currently in Phase 2 clinical trials for indications such as osteoarthritis and rheumatoid arthritis.

Other names: lornoxicam sustained-release tablets氯诺昔康缓释片

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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