sphinxolide B

Sphinxolide B is a naturally occurring marine macrolide compound classified as a diterpene lactone. It was originally isolated from the marine sponge Reidispongia coerulea and is notable for its complex structure and potent cytotoxic activity in preclinical models[2][8]. Sphinxolide B acts as a microfilament (actin) destabilizing agent and has been studied for its potential anticancer properties due to its ability to disrupt actin dynamics in cells[7][8]. Its mechanism involves binding to actin filaments and interfering with their stability—an action that can induce apoptosis or inhibit proliferation in cancer cells[7]. There are no approved therapeutic indications or marketed formulations of sphinxolide B; it remains an experimental compound primarily used in research settings.

Other names

N-((E,4R,5R,9S,10S,11S)-11-((3R,5Z,7E,11S,12S,13E,15R,17S,18S,19E,21S,23S,24R,25S,29S)-17,29-dihydroxy-3,15,21,23-tetramethoxy-5,12,18,24-tetramethyl-9,27-dioxo-10,26-dioxabicyclo(23.3.1)nonacosa-1(28),5,7,13,19-pentaen-11-yl)-4,10-dimethoxy-5,9-dimethyl-6-oxododec-1-enyl)-N-methylformamideN-methylformamide derivative of a macrolide lactone