Drug intelligence / Profile preview

SpHL-D-S

Development stage: Preclinical
Modality: Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
Administration: Intravenous

Overview

SpHL-D-S is a pH-sensitive liposomal formulation coencapsulating the anthracycline chemotherapy agent doxorubicin and the HMG-CoA reductase inhibitor simvastatin. Developed for the treatment of breast cancer, this combination therapy leverages the synergistic antitumor effects of statins and cytotoxic agents while utilizing pH-sensitive liposomes to improve drug delivery to the acidic tumor microenvironment. The formulation is designed to mitigate the cardiotoxicity typically associated with doxorubicin and protect simvastatin from degradation, thereby enhancing the safety profile and therapeutic index of the combination. Preclinical studies in murine breast cancer models have demonstrated reduced cardiac vacuolization and hepatic disorders compared to free drug combinations.

Other names: pH-sensitive liposomal doxorubicin and simvastatinSpHL-DOX-SIM

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)TOP2A (DNA topoisomerase II)DNA

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