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SPI-curcumin-zinc ternary nanocomplex
- Development stage
- Preclinical
- Modality
- Nanoparticles → Drug Delivery Systems
- Administration
- Oral
01
Overview
The SPI-curcumin-zinc ternary nanocomplex is a food-derived neuroprotective agent composed of soy protein isolate (SPI), curcumin, and zinc. Developed as a potential adjuvant therapy for neurodegenerative disorders, specifically Parkinson's disease, the complex functions by maintaining mitochondrial homeostasis through the activation of mitophagy. Its mechanism of action involves the dual modulation of the PINK1/Parkin and PI3K/AKT/mTOR signaling pathways. Preclinical studies in zebrafish models have demonstrated that the nanocomplex can preserve cerebrovascular integrity, increase cerebral mitochondrial density, and significantly improve locomotor functions such as swimming distance and speed by attenuating oxidative damage and restoring mitochondrial dynamics.
- Other names
- SPI-curcumin-Zn ternary complexSPI-curcumin-zinc nanocomplexsoy protein isolate-curcumin-zinc complex
02
Targets
PINK1 (PTEN-induced kinase 1)PRKN (E3 ubiquitin-protein ligase parkin)
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