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SpiN-Tec
- Development stage
- Phase 2
- Lead developer
- Universidade Federal de Minas Gerais
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
SpiN-Tec is a chimeric recombinant protein vaccine developed as a booster against COVID-19. It consists of a fusion protein (SpiN) that combines the Receptor Binding Domain (RBD) of the SARS-CoV-2 Spike protein with the Nucleocapsid (N) protein. The vaccine is formulated with CTVad1, a squalene-based emulsion adjuvant similar to MF59. Unlike many first-generation COVID-19 vaccines that focus solely on the Spike protein, SpiN-Tec is designed to induce a broader and more durable immune response by targeting the more conserved Nucleocapsid protein, thereby eliciting robust T-cell immunity alongside neutralizing antibodies. This approach is intended to maintain efficacy against emerging SARS-CoV-2 variants of concern. The vaccine was developed by researchers at the Federal University of Minas Gerais (UFMG) in Brazil with support from the Ministry of Science, Technology and Innovation (MCTI).
- Other names
- SpiN vaccineSpiN-Tec vaccine
02
Targets
N (Nucleocapsid protein)SARS-CoV-2 spike
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