spiperone

Spiperone is a typical antipsychotic drug of the butyrophenone class, primarily used as a dopamine antagonist that binds to dopamine (notably D2) and serotonin (5HT2A) receptors. It is licensed for clinical use in Japan under the brand name Spiropitan for the treatment of schizophrenia[2][4]. Spiperone has also been widely used as a research chemical, particularly in neuropharmacology and imaging studies. Beyond its antipsychotic effects, it has been identified through compound screening as an activator of calcium-activated chloride channels (CaCCs), suggesting potential therapeutic applications in cystic fibrosis by stimulating chloride secretion independently of CFTR[5]. Recent preclinical studies have shown that spiperone can induce cell cycle arrest and apoptosis in colorectal cancer cells by disrupting intracellular calcium kinetics, inducing endoplasmic reticulum stress, and affecting lipid metabolism[6][8].

Brand names

Spiropitan

Other names

spiroperidolespiperona