spiramycin

Spiramycin is a macrolide antibiotic and antiparasitic agent primarily used to treat various bacterial infections, including toxoplasmosis, especially in pregnant women to reduce the risk of fetal infection. It is mainly bacteriostatic but can be bactericidal at high concentrations. Spiramycin acts by inhibiting protein synthesis in bacteria through binding to the 50S ribosomal subunit, thereby blocking translocation and stimulating dissociation of peptidyl-tRNA from ribosomes. Its antibacterial spectrum includes Gram-positive cocci and rods, Gram-negative cocci, Legionellae, mycoplasmas, chlamydiae, some spirochetes, Toxoplasma gondii, and Cryptosporidium species. The drug was discovered as a product of Streptomyces ambofaciens in 1952/1954 and has been available for oral use since 1955[2][6][7].

Brand names

Rovamycin

Other names

Spiramycin ASpiramycin ISpiramycin 1Spiramycin1Spiramycin-1Foromacidin AForomacidine ADemycarosylturimycin HEspiramicina