spironolactone + furosemide

Spironolactone and furosemide are small molecule diuretics used in the management of chronic heart failure. Spironolactone is a mineralocorticoid receptor antagonist that prevents the binding of aldosterone, thereby reducing sodium retention and potassium loss, and potentially improving insulin resistance by inhibiting inflammatory cytokines like TNF-α and IL-6. Furosemide is a loop diuretic that inhibits the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle, promoting the excretion of water and electrolytes. This specific research context from Tottori University Hospital involved a crossover trial evaluating the differential effects of these two agents on glucose metabolism and insulin resistance in patients with stable chronic heart failure.

Brand names

LasilactoneFruselacSpiromide

Other names

spironolactone and furosemide