Drug intelligence / Profile preview

spirulina platensis extract

Development stage
Unknown
Modality
Small Molecules, Recombinant Proteins and Enzymes
Administration
Oral, Topical
01

Overview

**Spirulina platensis extract** is a concentrated preparation derived from the cyanobacterium *Arthrospira platensis* (syn. *Spirulina platensis*), commonly marketed as a dietary supplement and functional food ingredient[1][2][6]. It is notable for its exceptionally high protein content (up to 60%), rich profile of essential amino acids, vitamins (notably B12), minerals, polyunsaturated fatty acids (γ-linolenic acid), phycocyanin, carotenoids (β-carotene), polysaccharides (including calcium spirulan), and other antioxidant pigments[2][4][6]. \n**Mechanism of Action:** The extract exhibits several biological activities, mostly attributed to its bioactive compounds: \n- **Phycocyanin** and other pigments provide antioxidant, anti-inflammatory, immunomodulatory, and anti-cancer effects through inhibition of pro-inflammatory cytokines (e.g., COX-2 inhibition), induction of apoptosis, and scavenging free radicals[2][5][6].\n- **Polysaccharides (e.g., calcium spirulan)** display antiviral activities by inhibiting viral replication and entry[5][6]. \n- **γ-linolenic acid** and related lipids contribute to lipid-lowering and antidiabetic action[4][6]. \n- Additional compounds exert antihypertensive, antimicrobial, and neuroprotective effects through diverse mechanisms[3][6][7]. \n**Primary indications:** Investigated as a nutraceutical for chronic arsenic poisoning (with zinc)[5], metabolic syndrome, diabetes, hyperlipidemia, antioxidant supplementation, and potentially neurodegenerative diseases such as Alzheimer's and Parkinson's[7]. \nMost claims remain under investigation; spirulina platensis extract is primarily used as a dietary supplement.

Brand names
Apogen
Other names
spirulina platensisArthrospira platensis extractS. platensis extractspirulina extract
02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TNFA (Tumor necrosis factor alpha (soluble))CDKN1A (Cyclin-dependent kinase inhibitor 1A)NF-κB

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