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SPL-108 + paclitaxel
- Development stage
- Phase 1
- Lead developer
- Splash Pharmaceuticals
- Modality
- DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Subcutaneous (SPL-108), Intravenous (paclitaxel)
01
Overview
SPL-108 + paclitaxel is a **combination therapy** consisting of SPL-108, a targeted small molecule inhibitor, and paclitaxel, a standard cytotoxic chemotherapeutic agent. SPL-108 inhibits CD44-mediated induction of multidrug resistance, specifically reducing P-glycoprotein (ABCB1) expression and thereby reversing resistance to agents like paclitaxel and platinum drugs. Paclitaxel disrupts microtubule function, leading to cell cycle arrest and apoptosis, especially in rapidly dividing cancer cells. The combination is developed primarily to treat **platinum-resistant, CD44+ advanced ovarian epithelial cancers**, with early-phase trials suggesting favorable safety and antitumor activity. SPL-108 is supplied as a subcutaneous injection, and paclitaxel is administered intravenously[1][2][3][4][5].
- Brand names
- SPL-108 + paclitaxel
- Other names
- SPL-108/paclitaxelSPL-108 and paclitaxelSPL108 and paclitaxelSPL 108 and paclitaxel
02
Targets
CD44 (CD44 antigen)ABCB1 (P-glycoprotein)TUBB (Tubulin (alpha and beta subunits))
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