SPM-5185

SPM-5185 is a cysteine-containing organic nitric oxide (NO) donor, specifically characterized as N-nitratopivaloyl-S-(N'-acetylalanyl)-cysteine ethyl ester. It was developed for its potent vasodilatory and cytoprotective properties in cardiovascular models. Preclinical studies indicate that SPM-5185 markedly attenuates endothelial dysfunction, reduces infarct size in myocardial ischemia-reperfusion injury, inhibits intimal thickening after vascular injury, and accelerates endothelial regeneration. The mechanism is primarily linked to NO donation, resulting in vasodilation and anti-inflammatory effects via reduced neutrophil adhesion and superoxide generation[1][2][3][4][10]. SPM-5185 was under preclinical development by Schwarz Pharma for cardiovascular indications such as myocardial ischemia and vascular injury[7]. It is distinct for combining a nitrate ester functional group with a cysteine motif, making it a novel class of NO donor described in the literature[8].

Other names

N-nitratopivaloyl-S-(N'-acetylalanyl)-cysteine ethyl ester