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SPS-701
- Development stage
- Preclinical
- Lead developer
- University of Michigan
- Modality
- Peptides, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
SPS-701 (also known as 22A-DMPC) is a synthetic high-density lipoprotein (sHDL) mimetic being developed by TSRLabs (formerly TSRL) in collaboration with the University of Michigan for the treatment and prevention of sepsis. Composed of the ApoA-I mimetic peptide 22A complexed with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) phospholipids, SPS-701 forms nanodiscs that mimic the structure and function of natural HDL. In sepsis, circulating HDL levels drop precipitously, which correlates with poor clinical outcomes. SPS-701 acts by directly binding and neutralizing bacterial lipopolysaccharide (LPS/endotoxin), preventing its interaction with toll-like receptor 4 (TLR4) and subsequent downstream inflammatory signaling. Additionally, SPS-701 exhibits direct anti-inflammatory and endothelial-protective properties, helping to mitigate the systemic inflammatory response and prevent progression to septic shock.
- Other names
- 22A-DMPCHDL mimeticsHDL mimetics - Sepsissynthetic HDLsynthetic high-density lipoprotein
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