SR59230A

SR59230A is a **selective antagonist of the beta-3 adrenergic receptor (β3-AR)**, commonly used as a pharmacological tool in research to investigate β3-adrenergic receptor function[8][1][2][3][10][5]. Although initially described as highly selective for β3-adrenergic receptors, subsequent studies have demonstrated that SR59230A also acts as an **antagonist at α1-adrenoceptors** at higher concentrations, showing antagonistic effects on α1A, α1B, and α1D subtypes[1][8]. SR59230A has been used in studies on thermoregulation, cardiovascular function, lipolysis, metabolic pathways, and pulmonary arterial hypertension, among others[1][2][3][4][6]. It is a **small molecule drug** that is blood-brain barrier-permeable[5][10]. Originator: Sanofi-Synthelabo[7].

Other names

SR59230A hydrochlorideSR-59230A hydrochlorideSR 59230A hydrochloride