SRC3-KO Regulatory T cells

SRC3-KO Regulatory T cells are **regulatory T cells (Tregs) genetically modified to lack Steroid Receptor Coactivator 3 (SRC-3, also known as NCOA3)**. SRC-3 is a transcriptional coactivator highly expressed in Tregs and is critical for their immunosuppressive function. Deleting SRC-3 in Tregs impairs their ability to suppress immune responses. In murine cancer models, adoptive transfer of SRC3-KO Tregs into tumor-bearing mice leads to **complete and durable eradication of established tumors**, notably in breast and prostate cancer models, without causing systemic autoimmunity. Mechanistically, SRC3-KO Tregs exhibit altered gene expression profiles that cause them to preferentially infiltrate tumors, secrete interferon-γ (IFNγ), and activate the CXCL9/CXCR3 axis, thereby recruiting cytotoxic immune cells (such as CD8+ T cells and NK cells) into the tumor microenvironment. This effect is strictly dependent on local IFNγ signaling. The overall outcome is a potent and lasting anti-tumor immune response with minimal off-tumor effects. Therapeutically, SRC3-KO Regulatory T cells represent a novel, investigational form of adoptive cell therapy designed as an alternative to conventional immune checkpoint inhibitors, with the advantage of robust anti-tumor activity and low risk of autoimmunity[1][3][5][7].

Other names

Steroid receptor coactivator 3 knockout regulatory T cellsSRC-3 KO TregsSRC3 KO TregsSRC 3 KO TregsSRC-3-deleted TregsSRC3-deleted TregsSRC 3-deleted Tregs