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SRI-42718
- Development stage
- Preclinical
- Lead developer
- Oregon Health & Science University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
SRI-42718 is a first-in-class, orally available, non-nucleoside small molecule antiviral agent that targets the conserved non-structural protein 4 RNA-dependent RNA polymerase (nsP4-RdRp) of alphaviruses, including Chikungunya virus (CHIKV). Developed by Oregon Health & Science University in collaboration with Southern Research and the University of North Carolina School of Medicine, SRI-42718 blocks both genomic RNA (gRNA) and subgenomic mRNA (sgmRNA) synthesis, as well as viral protein production. In preclinical models of CHIKV infection, oral administration of SRI-42718 significantly reduces acute viremia, viral tissue burden, and virus-induced joint swelling, and also decreases viral RNA levels in joint-associated tissues during the persistent phase of infection.
- Other names
- SRI 42718SRI42718SRI-42718
02
Targets
NSP4 (Rotavirus non-structural glycoprotein 4)
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