Sri-9662

Sri-9662 is an experimental small molecule belonging to the pyrido[2,3-d]pyrimidine class. It is a synthetic lipophilic antifolate designed as an inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folate metabolism and DNA synthesis. The compound has been structurally characterized in complex with human DHFR and demonstrates potential antiparasitic and anticancer properties by interfering with folate-dependent metabolic pathways. Its primary use has been as a research tool or discovery agent rather than for clinical application[1][3][8].

Other names

6-[(Z)-2-(2,5-dimethoxyphenyl)ethenyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE