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SRNDC-03

Development stage: Preclinical
Lead developer: Sirius Therapeutics
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics

Overview

SRNDC-03 is a preclinical small interfering RNA (siRNA) therapeutic candidate developed by Sirius Therapeutics (also known as Sirius Natural) for the treatment of coagulation disorders. Functioning as a coagulant, the therapy is designed to promote blood clotting, likely through the targeted silencing of an endogenous anticoagulant factor. The specific molecular target is currently undisclosed. SRNDC-03 leverages the company's delivery technology, which enables tissue-specific targeting across the liver, adipose, heart, kidney, and central nervous system.

Other names: SRNDC-03-Sirius Natural-siRNA-Liver, Adipose, Heart, Kidney, or CNS targeted delivery (company's siRNA delivery routes)-Coagulant indication (coagulation disorder)

Targets

F11 (Coagulation Factor XI)

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