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SRNDM-01
- Development stage
- Preclinical
- Lead developer
- Sirius Therapeutics
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Subcutaneous
01
Overview
SRNDM-01 is a preclinical-stage small interfering RNA (siRNA) therapeutic being developed by Sirius Therapeutics for the treatment of hypertension. The drug utilizes siRNA-mediated gene silencing to target a specific, currently undisclosed, biological pathway involved in blood pressure regulation. It is designed for liver-targeted delivery using Sirius Therapeutics' proprietary siRNA delivery platform, which is capable of targeting multiple tissues including the liver, adipose tissue, heart, kidney, and central nervous system. SRNDM-01 is part of a broader pipeline of cardiometabolic programs aimed at addressing cardiovascular diseases through RNA interference.
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