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SRNDM-04

Development stage: Preclinical
Lead developer: Sirius Therapeutics
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics

Overview

SRNDM-04 is a preclinical small interfering RNA (siRNA) therapeutic candidate being developed by Sirius Therapeutics for the treatment of cardiometabolic diseases. The drug is part of the company's proprietary siRNA platform, which focuses on gene silencing for various therapeutic areas. SRNDM-04 is designed to target an undisclosed molecular mechanism and utilizes delivery technology capable of reaching tissues such as the liver, adipose tissue, heart, kidneys, or the central nervous system (CNS). It is currently in the pre-clinical/IND-enabling stage of development.

Targets

F11 (Coagulation Factor XI)

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