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SRNDM-05

Development stage: Preclinical
Lead developer: Sirius Therapeutics
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics

Overview

SRNDM-05 is a preclinical small interfering RNA (siRNA) therapeutic candidate being developed by Sirius Therapeutics for the treatment of cardiometabolic diseases. It is part of a broader pipeline of RNAi therapies designed to leverage the company's proprietary delivery platforms, which enable targeted delivery to various tissues including the liver, adipose tissue, heart, kidneys, and the central nervous system. As an siRNA, SRNDM-05 functions by inducing the degradation of specific messenger RNA (mRNA) transcripts, thereby silencing the expression of a target protein associated with cardiometabolic dysfunction. The specific molecular target for SRNDM-05 has not yet been disclosed by the company.

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