SRP + injectable platelet-rich fibrin

SRP + injectable platelet-rich fibrin (i-PRF) is an autologous combination therapy being evaluated by the University of Belgrade for the treatment of chronic periodontitis. This approach involves the application of i-PRF, a second-generation platelet concentrate derived from the patient's own blood, as an adjunct to scaling and root planing (SRP). i-PRF is obtained through low-speed centrifugation, which preserves a high concentration of platelets and leukocytes within a liquid fibrin matrix. Once injected into the periodontal pocket, the i-PRF matrix provides a sustained release of various growth factors, including vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and insulin-like growth factor (IGF). These factors work synergistically to promote angiogenesis, stimulate fibroblast proliferation, and enhance collagen synthesis, thereby facilitating the regeneration of periodontal tissues damaged by chronic inflammation.

Other names

SRP + i-PRFScaling and Root Planing + Injectable Platelet-Rich FibrinSRP + platelet-rich fibrin-University of Belgrade-chronic periodontitis